Bethesda公布《辐射3》的硬件需求其中最低硬件配置为：
操作系统 Windows XP/Vista
系统内存 1GB(XP) / 2GB(Vista)
处理器 Intel Pentium 4 2.4G，或与此相当
显卡 Direct X 9.0c兼容显卡，至少256MB显存(NVIDIA 6800或更佳 / ATI X850或更佳)
推荐配置
处理器 Intel Core 2 Duo
系统内存 2GB
显卡 Direct X 9.0c兼容显卡，512M显存(NVIDIA 8800系列 / ATI 3800系列)
以下显卡通过测试：
NVIDIA GeForce 200 series
NVIDIA GeForce 9800 series
NVIDIA GeForce 9600 series
NVIDIA GeForce 8800 series
NVIDIA GeForce 8600 series
NVIDIA GeForce 8500 series
NVIDIA GeForce 8400 series
NVIDIA GeForce 7900 series
NVIDIA GeForce 7800 series
NVIDIA GeForce 7600 series
NVIDIA GeForce 7300 series
NVIDIA GeForce 6800 series
ATI HD 4800 series
ATI HD 4600 series
ATI HD 3800 series
ATI HD 3600 series
ATI HD 3400 series
ATI HD 2900 series
ATI HD 2600 series
ATI HD 2400 series
ATI X1900 series
ATI X1800 series
ATI X1600 series
ATI X1300 series
ATI X850 series
